This information is intended for healthcare professionals based in Ireland.
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This information is intended for healthcare professionals based in Ireland.
If you are not a healthcare professional in Ireland, click here
AMPLIFY-EXT Clinical Trial
Choose ELIQUIS® for prevention of recurrent DVT and PE
In AMPLIFY-EXT, in patients receiving extended treatment for prevention of recurrent DVT and PE, ELIQUIS 2.5 mg BD demonstrated superior efficacy and no significant difference in the rates of both major and major/CRNM bleeding vs placebo1,2*
ELIQUIS is only licensed for prevention of recurrent VTE at a dose of 2.5 mg BD and initiated after 6 months of treatment with ELIQUIS 5 mg BD or another anticoagulant.2
Visit this page for more information on ELIQUIS dosing for DVT / PE.
ELIQUIS (apixaban) is indicated for prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation (NVAF), with one or more risk factors, such as prior stroke or transient ischaemic attack (TIA), age ≥75 years, hypertension, diabetes mellitus, symptomatic heart failure (NYHA Class ≥II); treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevention of recurrent DVT and PE in adults; and, prevention of VTE in adult patients who have undergone elective hip or knee replacement surgery.2
Footnotes:
- *The AMPLIFY-EXT clinical trial was a 12 month, randomised, double-blind trial in 2,482 patients with VTE who had been treated for 6–12 months with standard anticoagulation therapy or had completed treatment with ELIQUIS or enoxaparin / warfarin as participants in the AMPLIFY trial and for whom there was clinical uncertainty about the benefit of continuing treatment.1
- †The primary efficacy endpoint was the incidence of the adjudicated composite of recurrent symptomatic VTE or death from any cause related to VTE.1 Recurrent VTE included fatal or non-fatal PE and DVT.1
- ‡The primary safety endpoint was major bleeding.1 For patients who had more than one event, only the first was counted.1
- §The secondary safety endpoint was the composite of major or CRNM bleeding events.1 For patients who had more than one event, only the first was counted.1
- ¶This link is to a third-party site unaffiliated with Pfizer / BMS. Please abide by the terms of use of the site.
- BD = Twice Daily CI = Confidence Interval DVT = Deep Vein Thrombosis N = Total number of patients in either the ELIQUIS group or the placebo group n = Number of patients with event
- PE = Pulmonary Embolism RR = Relative Risk SmPC = Summary of Product Characteristics VTE = Venous Thromboembolism
References:
- Agnelli G et al. N Engl J Med 2013; 368: 699–708.
- ELIQUIS® (apixaban) Summary of Product Characteristics.
Reporting of suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via HPRA Pharmacovigilance at www.hpra.ie
Adverse reactions should also be reported to Bristol-Myers Squibb Medical Information on 1 800 749 749 or medical.information@bms.com